Originally native to southern Mexico and now cultivated in many tropical countries (including Brazil , India , Indonesia , South Africa , Vietnam and Sri Lanka ), the papaya plant has been touted by traditional healers for centuries as a source of powerful medicine. Not only is papaya fruit delicious and loaded with vitamins and phytochemicals, but other parts of the plant have been used historically to treat health problems too. 
Now University of Florida (UF) researcher Dr. Nam Dang and his colleagues in Japan have announced 
new evidence that the papaya fights cancer cells. In fact, they discovered that an extract made from dried papaya leavesproduced a dramatic anti-cancer effect against a broadrange of tumors grown in the laboratory — including cancers of the cervix, breast, liver, lungand pancreas. 
The study, recently published in theJournal of Ethnopharmacology, not only showed that papaya has a direct anti-tumor effect on a variety of malignancies, but it also documented for the first time that papaya leaf extract increases the production of key signaling molecules called Th1-type cytokines.
 
That’s important because this regulation of the immune system raises the strong possibility that the use of papaya could help the body’s own immune system to overcome cancers. In addition, it suggests papaya could be helpful in treating or preventing other 
health problems such as inflammation andautoimmune diseases. 
The research team found that papaya’s anti-cancer effects were strongest when cancer cells received larger doses of the papaya leaf extract — yet, unlike many mainstream cancer therapies, there were no toxic effects at all on normal cells.
 
In a statement to the media, Dr. Dang pointed out that the ability of papaya extract to stop cancer without toxicity is consistent with reports from indigenous populations in Australia and in his native Vietnam 
. 
 
 
What exactly does
 papaya do to halt malignancies? To find out, the researchers focused on a T-lymphoma cancer cell line. They discovered that at least one of the mechanisms that makes papaya extract a potent anti-cancer weapon is the natural compound’s ability to cause malignant cells — but not normal ones — to die. 
The researchers hope to follow up these experiments by eventually testing the papaya cancer treatment in animal and human studies. Up next for Dr. Dang and his colleagues: they’ve applied to patent a process to distill the papaya extract through the University of Tokyo and they are working to identify all the specific compounds in the papaya extract that are active against cancer cells.
 
To this end, Dr. Dang has partnered with Hendrik Luesch, a UF Shands Cancer Center professor of medicinal chemistry who is an expert in the identification and use of natural products for medical purposes. Dr. Luesch recently discovered yet another natural 
cancer fighter — a coral reef compound that blocks cancer cell growth in cell lines.